Blocking Blood Vessel Inflammation to Treat Joint Damage from Bleeding Disorders

This trial is testing a procedure called embolization to treat joint damage caused by repeated bleeding in people with hereditary bleeding disorders like hemophilia. The procedure uses tiny particles to block abnormal blood vessels in the affected joint, which aims to reduce swelling and pain. Researchers will track how well this treatment works over five years using imaging, physical tests, and quality-of-life surveys.

Repeated bleeding into joints can cause permanent damage, swelling, and disability in people with hereditary bleeding disorders. Current treatments don't always stop the underlying inflammation in the joint. This trial is exploring whether blocking the abnormal blood vessels causing the problem might reduce pain and improve how well the joint works.