Testing a new medication to prevent colorectal cancer in high-risk patients

This trial is testing a medication called ONC201 to see if it can help prevent colorectal cancer in people who are at high risk—like those with a family history of the disease or who have had multiple polyps removed. Researchers want to understand whether this medication is safe and whether it can change how polyps develop in your colon. You would take the medication by mouth once a week or once every three weeks for 13 weeks while doctors monitor your health and take tissue samples.

People with certain conditions, like familial adenomatous polyposis or a history of multiple polyps, have a very high risk of developing colorectal cancer. Right now, doctors mainly watch these patients closely and remove polyps when they find them. This trial is exploring whether this medication might help prevent polyps from forming or progressing in the first place.