Plain-English translation of NCT05633706 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing a swallowable capsule called the SIMBA capsule that collects tiny samples from your small intestine. This study aims to understand how the bacteria living in your gut might be connected to digestive symptoms and diseases. By studying these samples alongside your health history and symptoms, researchers hope to find patterns that could help diagnose and treat gut disorders in the future.
Many people suffer from digestive disorders like irritable bowel syndrome, Crohn's disease, and celiac disease, but doctors don't yet fully understand how the bacteria in your small intestine might contribute to symptoms. This medication aims to safely collect samples from deep in the gut where other methods can't easily reach, so researchers can discover whether specific bacterial imbalances could become a diagnostic tool.
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You will swallow up to 4 small capsules on up to 2 separate visits. The capsule collects a tiny sample from your small intestine and passes naturally in your stool, which you'll return to the study team. You'll also provide a regular stool sample and fill out questionnaires about your medical history, diet, exercise, mental health, and any digestive symptoms you experience. The whole study involves sharing information about your lifestyle and health alongside these samples so researchers can look for connections between your symptoms and gut bacteria.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Canada
Sponsor
Nimble Science Ltd.
Collaborators
Mitacs, University of Calgary
Enrollment target
~300 participants
Started
January 2023
Primary completion
June 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Gwen Duytschaever, PhD
Nimble Science Ltd.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.