Plain-English translation of NCT05640700 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how the bacteria living in your vagina may affect whether HPV infection leads to cervical cancer. This study will collect vaginal samples and health information from women without HPV, women with HPV, and women with cervical changes to map out these bacterial patterns and identify which microorganisms might protect you or increase your risk.
Most women who get HPV clear it on their own, but some develop persistent infections that can lead to cervical cancer. Scientists believe the balance of bacteria in your vagina may play a key role in determining who clears HPV and who develops precancerous changes—but they don't yet understand the exact mechanism. This study aims to identify that connection so doctors might one day prevent or reverse dangerous HPV infections by restoring healthy vaginal bacteria.
You would visit the clinic for a routine Pap smear or colposcopy, and researchers would collect a vaginal sample at that time. You would also share health information and medical history with the study team. That's it—there are no follow-up visits or ongoing treatments; this is a one-time sample collection designed to help scientists learn more about how vaginal bacteria relates to cervical cancer risk.
AI-generated summary from trial data · Aug 8, 2026 · Not medical advice
Israel
Sponsor
Hadassah Medical Organization
Enrollment target
~99 participants
Started
November 2022
Primary completion
December 2027
Age range
25 Years – 70 Years
Sex
Female only
Last updated on clinicaltrials.gov in October 2026.