Plain-English translation of NCT05642156 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a newer dialysis approach called sequential dialysis (which combines isolated ultrafiltration followed by conventional dialysis) works better than standard dialysis alone for patients with end-stage kidney disease. The study is looking at how these two methods affect your blood pressure and heart function during treatment, and whether one approach is gentler on your body than the other.
Many dialysis patients experience dangerous drops in blood pressure during treatment. Earlier research suggested that sequential dialysis might prevent these drops better than standard dialysis, but newer studies are needed to confirm whether this actually helps patients feel better and have fewer complications.
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You would receive 16 dialysis sessions over about 8 weeks, with a crossover design — meaning you'd try one dialysis method for 8 sessions, then switch to the other method for 8 sessions. During these sessions, researchers would monitor your blood pressure, heart function, and other vital signs to compare how your body responds to each approach. The study does not add extra time to your regular dialysis schedule.
AI-generated summary from trial data · Jul 8, 2026 · Not medical advice
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