Comparing cooling and compression methods to prevent nerve damage from chemotherapy

This study is testing whether applying cooling and compression (pressure) to your arms and legs during taxane chemotherapy can prevent or reduce peripheral neuropathy—a type of nerve damage that causes numbness, tingling, and weakness in the hands and feet. You will be randomly assigned to receive one of three types of treatment: cooling plus compression, continuous compression alone, or gentle pulsing compression. Researchers will track how many people develop nerve damage over one year.

Taxane chemotherapy is effective at treating cancer, but it commonly causes nerve damage in the hands and feet that can be painful and long-lasting. This trial is testing whether mechanical cooling and compression during treatment can protect the nerves from this damage.