Recruiting

Testing a drug-coated stent for narrowed neck arteries

Plain-English translation of NCT05644314 on ClinicalTrials.gov ↗ · Source last updated March 2023 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing a treatment for people whose vertebral arteries—major blood vessels in the neck that supply blood to the brain—have become dangerously narrowed due to atherosclerosis (plaque buildup). The treatment involves placing a special stent called Maurora® into the narrowed artery. This stent is coated with a medication designed to prevent the artery from narrowing again after the procedure.

Vertebral artery narrowing is a significant cause of stroke, particularly strokes affecting the back of the brain. While stents help restore blood flow immediately, the vessels can narrow again over time. This medication aims to reduce that risk by using a drug-coated stent, which has shown promise in earlier trials.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with significant narrowing in a vertebral artery (50% or more if you've had stroke symptoms, or 70% or more if you have no symptoms)
your doctor has determined that a drug-eluting stent is the right treatment for you
you are willing and able to take blood-thinning medications after the procedure
you fully understand the trial and voluntarily agree to participate

You likely don't qualify if…

you cannot take dual antiplatelet therapy (blood-thinning medications) due to medical conditions or severe bleeding disorders
you have an untreated brain aneurysm or one that cannot be safely treated
you have active gastrointestinal bleeding
you have had a heart attack or major stroke within the past 2 weeks
you have a known allergy or serious reaction to heparin, the medication coating the stent, anesthesia, or contrast dye

What participation looks like

If you qualify, you will undergo the stent placement procedure, which involves inserting a thin catheter into your artery and positioning the drug-coated stent at the narrowed site. After the procedure, you will need to take prescribed blood-thinning medications as directed. The study will follow your progress over time with follow-up visits to monitor how well the stent is working and whether your symptoms improve.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Trial locations(1 site)

China

Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong