Plain-English translation of NCT05646316 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether a newer, less extensive surgical approach can work as well as traditional surgery for early-stage uterine cancer while causing fewer problems with leg swelling and function. The study compares two ways surgeons can check the lymph nodes (small glands that filter fluid in your body) during hysterectomy (surgical removal of the uterus). Both approaches use a special dye to help identify the lymph nodes, but they differ in how many nodes are removed.
A common side effect of uterine cancer surgery is lymphedema — swelling and dysfunction in the legs that can last for years and significantly affect quality of life. This trial is testing whether removing fewer lymph nodes can prevent this complication while still finding any cancer that may have spread.
You likely qualify if…
You likely don't qualify if…
You would undergo minimally invasive hysterectomy surgery where surgeons use a special dye to map and identify lymph nodes. Depending on which group you are randomly assigned to, either fewer lymph nodes will be removed (if successfully mapped) or additional lymph nodes will be removed as standard procedure. After surgery, you would complete questionnaires about leg swelling and function, have your leg measurements taken at follow-up visits, and may provide optional blood samples. The study team will also track any imaging results and treatment decisions over time to understand how each approach affects your recovery and long-term quality of life.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States