A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis — Stella
Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.
(139 sites) United States
Heart Center Research Llc, Huntsville, Alabama Cardiovascular Res Found, Beverly Hills, California National Heart Institute, Beverly Hills, California Flourish Clinical Resrch Covin, Covina, California Valley Clinical Trials, Northridge, California Stanford University Medical Center, Palo Alto, California University Of California San Diego, San Diego, California UC San Francisco Medical Center, San Francisco, California Excel Medical Clinical Trials LLC, Boca Raton, Florida Nova Clinical Research LLC, Bradenton, Florida Flourish Res Acq LLC North Miami, Miami, Florida Inpatient Research Clinical LLC, Miami Lakes, Florida Advanced Research for Health Improvement LLC, Naples, Florida Midwest Heart and Vascular Spec, Overland Park, Kansas Tufts Medical Center, Boston, Massachusetts Massachusetts General Hospital, Boston, Massachusetts Massachusetts General Hospital, Boston, Massachusetts Brigham and Womens Hosp Harvard Med School, Boston, Massachusetts Brigham and Womens Hosp Harvard Med School, Boston, Massachusetts Henry Ford Hospital, Detroit, Michigan Henry Ford Hospital, Detroit, Michigan AA Medical Research Center, Flint, Michigan William Beaumont Hospital, Royal Oak, Michigan Minneapolis Heart Institute, Minneapolis, Minnesota University Of Minnesota, Minneapolis, Minnesota Overlook Medical Center, Summit, New Jersey Capital Cardiology Associates, Albany, New York New York Presbyterian Hospital, New York, New York Icahn School of Med at Mt Sinai, New York, New York Strong Memorial Hospital, Rochester, New York Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina Lindner Ctr At The Christ Hosp, Cincinnati, Ohio Ohio State University, Columbus, Ohio Perelman School of Medicine, Philadelphia, Pennsylvania Orion Medical, Houston, Texas Virginia Heart, Falls Church, Virginia Carient Heart and Vascular, Manassas, Virginia Austria
Novartis Investigative Site, Innsbruck, Tyrol Novartis Investigative Site, Linz Novartis Investigative Site, Vienna Novartis Investigative Site, Vienna Novartis Investigative Site, Vienna Belgium
Novartis Investigative Site, Genk, Limburg Novartis Investigative Site, Yvoir, Namur Novartis Investigative Site, Aalst, Oost Vlaanderen Novartis Investigative Site, Kortrijk, West-Vlaanderen Novartis Investigative Site, Roeselare, West-Vlaanderen Canada
Novartis Investigative Site, Cambridge, Ontario Novartis Investigative Site, North York, Ontario Novartis Investigative Site, Ottawa, Ontario Novartis Investigative Site, Montreal, Quebec Novartis Investigative Site, Montreal, Quebec Novartis Investigative Site, Montreal, Quebec Novartis Investigative Site, Québec, Quebec Czechia
Novartis Investigative Site, Hradec Králové Novartis Investigative Site, Jaroměř Novartis Investigative Site, Prague Novartis Investigative Site, Prague Novartis Investigative Site, Prague Denmark
Novartis Investigative Site, Esbjerg Novartis Investigative Site, Hvidovre Novartis Investigative Site, Roskilde Novartis Investigative Site, Viborg France
Novartis Investigative Site, Paris Novartis Investigative Site, Paris Novartis Investigative Site, Paris Novartis Investigative Site, Pessac Novartis Investigative Site, Poitiers Novartis Investigative Site, Rennes Germany
Novartis Investigative Site, Frankfurt am Main, Hesse Novartis Investigative Site, Kaiserslautern, Rhineland-Palatinate Novartis Investigative Site, Dresden, Saxony Novartis Investigative Site, Leipzig, Saxony Novartis Investigative Site, Ahaus Novartis Investigative Site, Berlin Novartis Investigative Site, Bonn Novartis Investigative Site, Essen Novartis Investigative Site, Hamburg Novartis Investigative Site, Hamburg Novartis Investigative Site, Lüneburg Novartis Investigative Site, Mannheim Novartis Investigative Site, München Israel
Novartis Investigative Site, Beersheba Novartis Investigative Site, Haifa Novartis Investigative Site, Haifa Novartis Investigative Site, Jerusalem Novartis Investigative Site, Jerusalem Novartis Investigative Site, Nahariya Novartis Investigative Site, Petah Tikva Novartis Investigative Site, Ramat Gan Novartis Investigative Site, Tel Aviv Italy
Novartis Investigative Site, Ancona, AN Novartis Investigative Site, Bergamo, BG Novartis Investigative Site, Bologna, BO Novartis Investigative Site, Brescia, BS Novartis Investigative Site, Caserta, CE Novartis Investigative Site, Cona, FE Novartis Investigative Site, Pozzilli, IS Novartis Investigative Site, Milan, MI Novartis Investigative Site, Milan, MI Novartis Investigative Site, Milan, MI Novartis Investigative Site, Padova, PD Novartis Investigative Site, Pordenone, PN Netherlands
Novartis Investigative Site, Amsterdam, North Holland Novartis Investigative Site, Amsterdam, North Holland Novartis Investigative Site, Rotterdam, South Holland Novartis Investigative Site, Rotterdam, South Holland Novartis Investigative Site, Nieuwegein, Utrecht Portugal
Novartis Investigative Site, Alcabideche Novartis Investigative Site, Braga Novartis Investigative Site, Coimbra Novartis Investigative Site, Vila Nova de Gaia Spain
Novartis Investigative Site, Cáceres, Extremadura Novartis Investigative Site, Córdoba Novartis Investigative Site, Madrid Novartis Investigative Site, Madrid Novartis Investigative Site, Madrid Novartis Investigative Site, Madrid Novartis Investigative Site, Salamanca Novartis Investigative Site, Valencia Switzerland
Novartis Investigative Site, Basel Novartis Investigative Site, Geneva Novartis Investigative Site, Lausanne Novartis Investigative Site, Lugano Novartis Investigative Site, Zurich United Kingdom
Novartis Investigative Site, Reading, Berkshire Novartis Investigative Site, Portadown, Nothern Ireland Novartis Investigative Site, Edinburgh Novartis Investigative Site, Leicester Novartis Investigative Site, Liverpool Novartis Investigative Site, London Novartis Investigative Site, London Novartis Investigative Site, Londonderry Novartis Investigative Site, Manchester Novartis Investigative Site, Middlesbrough Novartis Investigative Site, Norwich Novartis Investigative Site, Tyne and Wear
Key details Sponsor
Novartis Pharmaceuticals
Enrollment target
~502 participants
Primary completion
March 2030
Age range
50 Years – 80 Years
Last updated April 2026
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