Plain-English translation of NCT05646485 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Bladder Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether simple urine tests—including routine urinalysis and newer molecular marker tests that look for cancer-related changes in urine—can detect bladder cancer in its earlier, more treatable stages. The trial will enroll 1,000 people at high risk for bladder cancer and screen them regularly to see if these urine tests catch the disease before symptoms appear.
Bladder cancer is often found late, when it's already advanced and harder to treat. While doctors screen for colon, breast, and cervical cancers routinely, there's no standard screening method for bladder cancer yet. This trial aims to find out whether regular urine screening can catch the disease earlier, when treatment is less burdensome and outcomes are better.
You likely qualify if…
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You would visit the study clinic every 6 months for 2 years to provide urine samples for screening. Depending on your urine test results, you may need additional tests like imaging or a cystoscopy (a procedure to look inside the bladder). If anything suspicious is found, you'll receive standard treatment—the study isn't testing a new drug or asking you to avoid your normal medical care.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Sponsor
University of Texas Southwestern Medical Center
Collaborators
Wilson Charitable Foundation Trust, Pacific Edge Limited
Enrollment target
~1,000 participants
Started
May 2023
Primary completion
April 2027
Age range
50 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yair Lotan, MD
University of Texas Southwestern Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.