Plain-English translation of NCT05651204 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying brain electrical activity in children with Dravet syndrome (a genetic form of severe epilepsy caused by SCN1A gene mutations) to develop new ways to measure a brain chemical called GABA that controls seizures. This study compares brain activity patterns in children with Dravet syndrome to healthy children the same age. The goal is to create a simple, non-invasive test that could help doctors monitor this brain chemical and guide future treatments.
Dravet syndrome happens when there is a problem with how the brain controls excitement and calm through a chemical messenger called GABA. There is currently no simple way to measure GABA levels in a living person's brain, which makes it hard to understand what is happening and to develop better treatments. This study aims to create a non-invasive measurement tool that could help doctors monitor GABA and test new therapies.
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If you join this study, your child will complete non-invasive brain electrical activity measurements (such as EEG recordings) while they rest or perform simple tasks. The study compares children with Dravet syndrome to healthy children of similar ages to look for differences in brain activity patterns. Based on the study design, visits would involve the brain activity tests, and no experimental medication is being given — researchers are simply measuring and analyzing existing brain activity.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
United States
Sponsor
Cook Children's Health Care System
Collaborators
Encoded Therapeutics
Enrollment target
~36 participants
Started
September 2022
Primary completion
September 2024
This trial's estimated completion date has passed — the record may not be fully up to date.
Last updated on clinicaltrials.gov in December 2022.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sabrina Shandley, PhD
Cook Children's Health Care System
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.