Plain-English translation of NCT05654012 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are trying to understand why some teenagers develop migraines and others don't. This study will follow about 250 teenagers over time, comparing those who already have migraines with those who don't (especially those whose parents or relatives have migraines). By looking at brain scans, testing how sensitive you are to pain, measuring hormone levels, and asking about your health, researchers hope to find early warning signs that could help predict and eventually prevent migraines.
Migraines are common in teenagers but we don't fully understand what causes them to start or why some young people are more likely to develop them than others. This research could help doctors identify at-risk teenagers earlier and find better ways to prevent migraines before they become a problem.
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You would visit the research center for baseline testing and then follow-up visits over time. During each visit, you'll have an MRI scan of your brain (which takes about an hour), complete sensory testing to measure how your body responds to pain, meet with a headache specialist to assess your migraine status, and provide blood and saliva samples for hormone testing. You'll also fill out surveys about your health and development. Between visits, you may be asked to collect saliva samples at home for a couple of days.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States