Plain-English translation of NCT05654012 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand why some teenagers develop migraines and what changes happen in the brain and body when they do. This study will follow teenagers aged 10–13 over time, some with migraines and some without, to identify the warning signs and biological changes that predict migraine onset. By studying brain scans, hormone levels, and pain sensitivity, the research team hopes to discover what puts certain teenagers at risk.
Migraines are common in teenagers but doctors don't yet understand what causes them to start or who is most likely to develop them. This knowledge could eventually help doctors predict and prevent migraines before they begin.
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You and your parent or guardian will start by completing surveys to confirm you are eligible. Then you'll visit the research clinic, where you'll have a one-hour brain scan (MRI), complete pain sensitivity tests, meet with a headache specialist to confirm whether you have migraines, and provide blood and saliva samples to check hormone levels. You may also be asked to collect saliva samples at home for a couple of days after each visit. Depending on the study design, you may have follow-up visits to see if anything has changed.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
United States