Plain-English translation of NCT05655195 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new approach to Alzheimer's disease using a home device that delivers light and sound stimulation at a specific frequency (40Hz). Research in mice showed that this type of stimulation can reduce harmful protein buildup in the brain and improve memory, and now researchers want to see if it works safely in people with mild Alzheimer's disease.
Alzheimer's disease damages the brain's ability to form and keep memories, and there are currently limited treatment options. Early research suggests that stimulating the brain at this specific frequency could help protect memory by reducing toxic proteins and boosting the brain's natural activity patterns.
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You will take home a light and sound device to use for one hour every day for six months. Half of participants will receive the active treatment (40Hz stimulation), and half will receive a sham treatment that looks identical but delivers no actual stimulation—neither you nor the researchers will know which you're receiving. You'll also wear a fitness tracker to monitor sleep and visit MIT three times for tests including brain scans, memory assessments, blood tests, and EEG recordings.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
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