Plain-English translation of NCT05656469 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing whether a genetic test can help psychiatrists prescribe better medications for people with depression, anxiety, or psychotic disorders. Some people don't respond well to psychiatric medications or experience side effects because of differences in how their bodies process drugs — and these differences are partly written in their genes. This study compares two groups: one group will receive medications chosen based on their genetic test results, while the other group will receive medications chosen the usual way, without genetic testing.
Many people with mental health conditions struggle with psychiatric medications because the standard approach to prescribing doesn't account for individual genetic differences in how the body processes drugs. This trial exists to find out whether using genetic information upfront can help doctors pick the right medication at the right dose the first time, reducing side effects and improving how well the treatment works.
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You will be randomly assigned to one of two groups for 24 weeks. If you're in the genetic testing group, you'll have a genetic test done, and your doctor will use those results to personalize your medication choice and dose. If you're in the standard care group, your doctor will prescribe the medication the usual way without knowing your genetic information (though you'll receive your genetic results after the study ends). In both groups, you'll attend regular appointments to check how the medication is working, and you'll use your smartphone to help researchers monitor your progress.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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