Plain-English translation of NCT05658913 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer's Disease research guide →This research study uses a special type of brain imaging called a PET/CT scan with a radiotracer called to take pictures of tau, a protein that builds up in the brains of people with Alzheimer's disease. Researchers want to understand how this protein relates to other markers of Alzheimer's that they've already measured in participants. By studying these patterns, scientists hope to better understand how Alzheimer's disease develops and progresses.
Tau protein buildup is a hallmark of Alzheimer's disease, but doctors don't yet fully understand how it relates to other changes happening in the brain. This study aims to fill that knowledge gap so researchers can develop better ways to diagnose and treat Alzheimer's in the future.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll visit the imaging center for a single PET/CT brain scan appointment. Before the scan, you'll complete screening assessments to confirm you're ready. During the scan itself, you'll receive an injection of the radiotracer (a safe, short-lived radioactive dye) and then lie still in the imaging machine for a period of time while it takes detailed pictures of your brain. The scan typically takes about an hour, and you'll need your study partner present with you during the visit.
AI-generated summary from trial data · Jul 16, 2026 · Not medical advice
United States
Sponsor
University of Pennsylvania
Collaborators
Massachusetts General Hospital
Enrollment target
~100 participants
Started
March 2023
Primary completion
December 2027
Age range
18 Years – 120 Years
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jacqueline Lane
University of Pennsylvania Department of Neurology at the Perelman School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.