Plain-English translation of NCT05664035 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is looking for a specific immune system problem called polysaccharide antibody deficiency (SPAD) in adults who keep getting serious bacterial infections despite having normal-looking immune systems. Researchers will give you a pneumococcal vaccine (PPV23), take blood samples to see how your body responds, and then follow you for a year to see if treatment helps prevent future infections.
Some people get repeated serious infections even though their standard immune tests look normal. This study wants to find out how often this specific antibody problem occurs and whether treating it—with preventive antibiotics or immune therapy—can help patients stay healthier.
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You will visit the hospital three times over about 2 months for blood tests and a vaccine. At your first visit, doctors will take a blood sample and give you a pneumococcal vaccine (PPV23). About a month later, you'll return for another blood sample to measure your immune response. If the tests show you have this antibody deficiency, your doctor may start you on preventive antibiotics or immune therapy. One year after starting treatment, you'll return for a final visit to check whether the treatment has reduced your infections and improved your quality of life.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
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