Adding brain-protective drugs to standard glioblastoma treatment

This trial is testing whether three FDA-approved medications—gabapentin, sulfasalazine, and memantine—can help fight glioblastoma when added to the standard treatment of chemotherapy combined with radiation. These medications work by blocking glutamate, a chemical that glioblastoma tumors use to grow and spread. The study will determine if adding this medication combination is safe and effective enough to test in a larger trial.

Glioblastoma is an aggressive brain cancer with a poor prognosis despite current treatment. Researchers believe that blocking glutamate—a key chemical the tumor uses to survive and grow—could improve outcomes. This medication approach uses drugs that are already safely used for other conditions, so researchers want to test whether repurposing them for cancer treatment could help.