Testing a probiotic treatment for mild to moderate ulcerative colitis

Plain-English translation of NCT05666960 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This study is testing a probiotic medication called to see if it is safe and helpful for people with mild to moderate ulcerative colitis. Researchers will have you take the medication by mouth and will measure how well it works by checking your symptoms, blood samples, and stool samples. They want to understand how this treatment affects inflammation in your gut.

Ulcerative colitis causes painful inflammation in the colon and rectum, and current treatments don't work well for everyone. Researchers believe that this medication might help reduce inflammation by restoring healthy bacteria in the gut, offering a new option for people who need better symptom control.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have been diagnosed with mild to moderate ulcerative colitis confirmed by colonoscopy
you have been on a stable dose of aminosalicylate medication for at least 4 weeks before enrollment
you are willing to use birth control during the study and for 30 days after finishing the medication
you can commit to not receiving any vaccinations during the study period

You likely don't qualify if…

you are pregnant, planning to become pregnant, or breastfeeding
you have severe ulcerative colitis
you have an active infection or have had COVID-19 in the past 3 months
you are currently taking immunosuppressant medications, anti-TNF drugs, or other biologic treatments for ulcerative colitis
you have taken other probiotics in the past week or are allergic to probiotics

What participation looks like

You will take the probiotic medication by mouth as directed by the study team. Throughout the study, you will complete visits where doctors will examine you, ask about your symptoms, and collect blood and stool samples to measure inflammation and how the medication is working. The study involves both a single dose phase and a repeat dosing phase to make sure the treatment is safe and effective.

AI-generated summary from trial data · Jun 23, 2026 · Not medical advice

Trial locations(5 sites)

United States

Amicis Research Center, Valencia, California

AP Medical Research LLC, Miami, Florida

Edward Jenner Research Group, LLC, Plantation, Florida

Adtremed Research Clinic, Tampa, Florida

Mayo Clinic, Rochester, Minnesota