Plain-English translation of NCT05685368 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This study is testing Acceptance and Commitment Therapy (ACT), a coping skills program designed to help Black teenagers and young adults with sickle cell disease manage stress and improve their mental health. The therapy focuses on helping you deal with the unique stresses that come with living with sickle cell disease and dealing with race-related stress. You would join a 10-session group where you learn practical tools to handle difficult emotions and improve your quality of life.
Many young people with sickle cell disease struggle with depression, anxiety, and stress — but there aren't many programs designed specifically for them. This research tests whether this therapy program can help reduce those mental health challenges and help you feel better overall.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would join a small group (8–10 teens) for 10 weekly therapy sessions held online. Each session teaches you skills to cope with stress and improve your mental health. A control group will be offered the same therapy 3–4 months later. You may also be asked to join an advisory board to help shape the program, which means attending meetings and sharing your feedback about what works best for you.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States