Plain-English translation of NCT05691491 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a combination of two medications: and (M1774). The goal is to figure out the right dose of these drugs when given together, and to see how well they work against advanced cancers. This is an early-stage study that will help doctors understand if this medication combination is both safe and effective enough to pursue further.
Some advanced cancers, especially colorectal cancer, stop responding to standard treatments. This medication combination targets cancer cells in a different way, and researchers believe combining these drugs might work better than using them alone—especially for patients who have limited options left.
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You would take by mouth on days 1–5 of each cycle, and by mouth daily on days 1–7 of each cycle, with cycles repeating every 28 days. Throughout the trial, you'll have CT or MRI scans, blood tests, and a biopsy at the start (and possibly during or at the end). After treatment ends, you'll have follow-up visits at 4 weeks and then every 3 months for up to 2 years to monitor your health and how you're doing.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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