Plain-English translation of NCT05692635 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether regular brain MRI scans can help find cancer that has spread to the brain before it causes symptoms in people with advanced lung cancer. The study follows patients who have already completed radiation therapy to see if catching brain spread earlier with these scans can prevent serious symptoms from developing.
When lung cancer spreads to the brain, it often causes serious symptoms that can affect quality of life and treatment options. This study wants to see if catching this spread earlier with routine scans—before symptoms appear—can help improve outcomes and give doctors more time to treat it.
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You will receive brain MRI scans on a regular schedule for up to 14 months or until a brain metastasis is detected, whichever comes first. The scans may include an injection of contrast dye to help doctors see your brain more clearly. You will also provide a blood sample at the start of the study. Overall, you will be followed for approximately 780 days (about 2 years) from your first radiation treatment.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Wake Forest University Health Sciences
Collaborators
National Cancer Institute (NCI)
Enrollment target
~60 participants
Started
August 2023
Primary completion
April 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Deonna Asbury
Wake Forest Baptist Comprehensive Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.