Plain-English translation of NCT05699226 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new way to deliver electroconvulsive therapy (ECT) — a brain stimulation treatment for severe depression. Instead of using the same electrical dose for everyone, researchers will customize the electrical strength based on each person's individual brain anatomy. The goal is to help more people improve without causing unwanted changes to memory or thinking.
Current depression treatments don't work for everyone, and some people need ECT when other options fail. However, the standard way of delivering this treatment uses a one-size-fits-all electrical dose, which means some people don't improve enough while others experience thinking or memory problems. This trial is designed to see if personalizing the dose can help more people get better without the unwanted side effects.
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You will visit the clinic three times: before your first treatment, after your sixth treatment, and after your complete treatment series. At each visit, you'll have a brain scan, answer questions about your mood, and complete brief thinking and memory tests. During the treatment phase, you'll receive ECT sessions (the number will depend on your treatment plan). You'll be randomly assigned to receive either a personalized electrical dose or the standard fixed dose, and your progress will be carefully tracked throughout.
AI-generated summary from trial data · Jul 8, 2026 · Not medical advice
United States