Plain-English translation of NCT05701254 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 1 Diabetes research guide →Researchers want to understand why people with type 1 diabetes often have weaker bones and break bones more easily, even though their bone density may look normal on standard scans. This study collects small bone samples from the hip to examine the actual quality and structure of bone tissue in women with type 1 diabetes compared to women without diabetes. By studying these samples closely, scientists hope to learn what makes diabetic bones more fragile.
People with type 1 diabetes have a higher risk of breaking bones, but doctors don't fully understand why — standard bone density tests don't always catch the problem. This study aims to identify the specific changes in bone quality caused by diabetes so that better screening and treatment options can be developed.
You will visit the research clinic four times over 6–8 weeks. At your first visit, you'll have a physical exam, a bone density scan, blood tests, and an EKG heart check. At the second visit, you'll receive an antibiotic (tetracycline) to help mark your bone. At the third visit, you'll have the bone biopsy procedure — two small samples taken from your hip bone under local anesthesia — plus another blood draw. At your final visit, the stitches will be removed. The study recruits matched pairs: each person with type 1 diabetes is paired with a healthy volunteer without diabetes who undergoes the same visits and procedures.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States