Plain-English translation of NCT05704036 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Cystic Fibrosis research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether transdermal estradiol—an estrogen patch applied to your skin once a week—can help improve bone health and quality of life in young women with cystic fibrosis who have low estrogen levels. The study has two parts: one that tracks how different types of birth control affect bone health, and another that tests whether the medication is safe and practical to use in this group.
Young women with cystic fibrosis often have low estrogen levels, which can lead to weak bones and an increased risk of fractures. This medication might help protect bone health during these important years when bone strength is still developing.
You likely qualify if…
You likely don't qualify if…
If you join the observational part, you'll have three visits over one year where researchers will take blood samples, do bone density scans and x-rays, and ask you questions about your health. If you qualify for the medication part, you'll apply an estrogen patch once a week for 12 months, have four study visits (with blood draws and bone scans at the first and last), and answer brief surveys between visits about how you're feeling.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States