Plain-English translation of NCT05705414 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether amino acid supplements — specifically and a combination of essential amino acids — can help reduce fatigue, improve physical strength, and support brain function in people with end-stage kidney disease who receive dialysis three times a week. Researchers want to understand whether one amino acid alone or a combination works better, and whether these supplements could help you feel more energized and capable during and after your dialysis treatments.
People with end-stage kidney disease often experience severe fatigue and muscle weakness that make daily life difficult. This medication may help address these problems by providing nutrients that the dialysis process or the disease itself may deplete, potentially improving quality of life.
You likely qualify if…
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You would attend your regular dialysis sessions at the study center, where researchers would give you amino acid packets to take during some of your treatment days. The study involves taking two different types of supplements — one at a time — with a break between them, so you'll try both and researchers can compare how each affects your fatigue, strength, and mental clarity. You'll also complete some simple tests, like grip strength tests and thinking/memory assessments, to help measure any improvements.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
The University of Texas Health Science Center at San Antonio
Collaborators
National Center for Advancing Translational Sciences (NCATS), IIMS-UT Health San Antonio
Enrollment target
~28 participants
Started
October 2024
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 64 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Subrata Debnath, PhD
The University of Texas Health Science Center at San Antonio
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.