Plain-English translation of NCT05709574 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether tadalafil, a medication commonly used for blood pressure and erectile dysfunction, can boost the immune system and help chemotherapy work better against stomach cancer. You would take tadalafil alone for 2 weeks, then combine it with standard chemotherapy for about 8 weeks before your planned surgery. The research team believes this medication may help your body's immune system fight the cancer more effectively.
Even with current treatments, stomach cancer has poor survival rates. Scientists have discovered that this medication may reduce immune-suppressing cells in the tumor, allowing chemotherapy and your body's natural defenses to work more powerfully together.
You would start by taking tadalafil pills daily for 2 weeks while the research team monitors you with blood tests and possibly imaging. Then you would continue the medication while also receiving standard chemotherapy infusions over about 8 weeks—this happens before your scheduled surgery. Throughout the study, the team will collect blood and tissue samples to understand how the medication affects your immune system and tumor.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
United States