Plain-English translation of NCT05710549 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating how the brain's networks that handle personal memories change in people with mild cognitive impairment — a condition where memory loss is more noticeable than typical aging but not yet severe dementia. Researchers will use advanced brain imaging (called high-density EEG) to measure electrical activity in your brain while you recall personal memories, and then apply a gentle, non-invasive form of brain stimulation called transcranial alternating current stimulation to see if it can help improve memory function. The goal is to understand the underlying brain mechanisms of memory loss so that better treatments can be developed in the future.
Scientists know that changes in brain networks happen long before memory problems become obvious, but we don't fully understand the detailed mechanisms causing these changes. This research aims to fill that gap by precisely mapping what goes wrong in the brains of people with mild cognitive impairment, which could eventually lead to earlier detection and new treatments.
You likely qualify if…
You likely don't qualify if…
If you have mild cognitive impairment, you will complete three separate laboratory sessions where you wear a cap with many small sensors that record your brain's electrical activity while you recall personal memories. During some sessions, you will also receive gentle electrical stimulation (transcranial alternating current stimulation) applied to your scalp for about 20 minutes while performing memory tasks. Healthy volunteers (younger and older adults) will complete the brain imaging portion without the stimulation. The study team will also perform cognitive tests and review your medical history to ensure you're a good fit for the research.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
Switzerland
Sponsor
Lucie Bréchet
Enrollment target
~120 participants
Started
April 2022
Primary completion
May 2027
Age range
18 Years – 85 Years
Last updated on clinicaltrials.gov in July 2025.
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Central contact
Lucie Bréchet, PhD
University of Geneva (UNIGE)
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