Testing Heart Artery Function in Patients With Chest Pain and Clear Arteries

This trial is studying a specialized heart test using acetylcholine — a naturally occurring substance — to check how your heart's arteries respond during a standard heart catheterization procedure. The test is designed to find hidden spasms or problems with blood flow in patients who have chest pain or heart attack symptoms but whose coronary arteries appear normal on standard imaging. Researchers want to understand how safe and useful this test is for diagnosing the real cause of your symptoms.

Many patients have chest pain or even heart attacks, but their coronary arteries look normal on standard tests. This can leave them without a clear diagnosis or treatment plan. Recent research suggests that invisible problems with how heart arteries function — rather than physical blockages — may be causing their symptoms, and the new test could help identify these hidden problems so doctors can treat them better.