Plain-English translation of NCT05720468 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether regular exercise can help protect your thinking and memory as Parkinson's disease progresses. Researchers know that exercise has powerful anti-aging effects and can improve cognition in Parkinson's patients, but they want to understand exactly how it works. This trial will measure changes in your cognition and in biological markers of aging found in your blood, saliva, and cerebrospinal fluid after 26 weeks of supervised home-based exercise.
Cognitive impairment—trouble with thinking, memory, and mental processing—often develops early in Parkinson's disease and worsens over time, affecting quality of life. This study aims to identify exactly which biological changes from exercise protect the brain and slow cognitive decline, which could open new ways to help people with Parkinson's stay mentally sharp longer.
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You will be randomly assigned to either start the exercise program right away or wait 26 weeks while continuing your normal activity level. If you are in the exercise group, you will exercise at home 5 days per week for 26 weeks under virtual supervision from trainers—3 days of treadmill work and 2 days of resistance training. You will complete cognitive tests and give blood, saliva, and cerebrospinal fluid samples at the beginning and end of the 26-week period to measure whether the exercise helps protect your thinking and changes biological markers of aging.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States