Plain-English translation of NCT05720468 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial examined whether a structured home exercise program could help slow or prevent thinking and memory problems in people with Parkinson's disease. Half of the participants received 26 weeks of guided exercise training (combining treadmill and strength work), while the other half continued their usual activity. Researchers measured changes in thinking ability and looked at biological markers in blood, saliva, and spinal fluid to understand how exercise might protect the brain.
Cognitive decline and dementia affect most people with Parkinson's disease and greatly reduce quality of life. Exercise has shown promise in improving brain health, but researchers needed to understand which biological changes drive this benefit and whether a practical home-based program could actually work.
Participants were randomly assigned to either an exercise group or a control group. Those in the exercise group trained at home 5 days per week for 26 weeks under virtual guidance from exercise trainers—3 days of treadmill work and 2 days of strength training. All participants had thinking and memory tests at the start and end of 26 weeks, and researchers collected blood, saliva, and spinal fluid samples to measure biological markers of aging and stress.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
United States
Sponsor
University of California, San Francisco
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Enrollment target
~31 participants
Started
July 2023
Primary completion
May 2026
Age range
40 Years – 80 Years
Last updated on clinicaltrials.gov in June 2026.