Plain-English translation of NCT05723679 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research is testing whether a special breathing gas mixture — made of oxygen and helium (HeO2) — can help people with heart failure and obesity exercise with less shortness of breath. The study first observes how obesity and heart failure affect your breathing during exercise, then tests whether this special gas mixture improves your ability to exercise and reduces breathlessness.
People with heart failure and obesity often feel severely short of breath during activity, which limits how much they can exercise and move around. This trial is investigating whether reducing the physical work your breathing muscles have to do could help you breathe easier and stay active longer.
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You will have screening visits that include exercise testing, lung function tests, and bone density scans. Then on two separate days at least 24 hours apart, you will breathe either the special helium-oxygen gas mixture or regular room air while exercising, in random order. The study team will measure how short of breath you feel and how long you can exercise with each gas mixture.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States