Recruiting

Testing a new cancer drug in patients with advanced tumors

Plain-English translation of NCT05725291 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated October 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

This is one of the first times this treatment has been tested in people.

What is this trial?

This is a first-in-human study of , a new experimental cancer medication designed to treat people with advanced solid tumors. Researchers will give increasing doses of this medication to small groups of patients to find the safest and most effective dose. The study will also measure how well the medication works against cancer and what side effects patients experience.

People with advanced cancers that have already been treated with standard therapies often have few options left. This medication represents a new approach to fighting these cancers, and this trial is the first step to see if it can help patients when other treatments have stopped working.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with an advanced solid tumor that cannot be surgically removed
you have already received at least one prior cancer treatment and your cancer is still growing or has come back
your overall health and organ function are adequate enough to tolerate the study medication
you are willing to use effective birth control throughout the study and for at least 12 weeks after treatment ends

You likely don't qualify if…

you have cancer that has spread to your brain or central nervous system
you have active eye problems including uncontrolled glaucoma or certain types of vision loss
you have had a severe skin reaction to previous medications, such as Stevens-Johnson syndrome
you have had major surgery within the past 4 weeks or have not recovered from a recent surgical procedure
you are currently taking another cancer medication or have taken one within the past 3 weeks

What participation looks like

You will receive increasing doses of the experimental medication, with small groups of patients tested at each dose level to determine safety. You will have regular study visits to check your health, provide blood samples, and have imaging tests to see how your cancer is responding. The study will carefully monitor you for any side effects and measure how your body processes the medication over time.

AI-generated summary from trial data · Oct 7, 2026 · Not medical advice

Trial locations(10 sites)

United States

Sarah Cannon Research Institute, Denver, Colorado

Mary Crowley Cancer Research Centers, Dallas, Texas

American Samoa

University of California San Francisco Cancer Center, San Francisco, California

Carolina BioOncology Institute, LLC, Cary, North Carolina

Australia

Macquarie University Hospital, Sydney, New South Wales