Plain-English translation of NCT05727787 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new radiation therapy approach called vGRID SBRT for people with advanced liver cancer that cannot be surgically removed. The treatment works by giving very high radiation doses to part of the tumor while giving lower doses to the rest, which may allow doctors to safely use stronger radiation than current standard treatments. The goal is to find the highest safe dose that can control larger tumors without harming nearby organs.
Current radiation therapy for liver cancer is limited by the risk of damaging healthy liver and nearby organs if doctors use very high doses. This trial exists to see if the new treatment technique can safely deliver much stronger radiation doses than currently possible, which could help control larger cancers that are hard to treat.
You likely qualify if…
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You will receive a single radiation therapy treatment on one day using the new vGRID technique. Before treatment, you'll have imaging and planning scans to map exactly where the radiation should go. The study will start with lower radiation doses and gradually increase them in different groups of patients to find the safest highest dose. You'll be followed with regular checkups and imaging scans to see how well the treatment works and monitor for any side effects.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Sponsor
University of Kansas Medical Center
Collaborators
Varian Medical Systems
Enrollment target
~18 participants
Started
February 2023
Primary completion
August 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Lauren Strider-Birkeness
University of Kansas Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.