Plain-English translation of NCT05728268 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether dose-dense chemotherapy — a way of giving chemotherapy drugs in shorter intervals rather than spread out over time — works better for women with a specific type of breast cancer. This breast cancer type is hormone receptor-positive, HER2-negative, and has a high growth rate. Researchers want to see if this more intensive schedule can reduce the chance the cancer comes back.
Research shows that dose-dense chemotherapy helps many breast cancer patients, but doctors aren't sure which women with this particular type of breast cancer benefit most from it. This trial will help identify which patients are most likely to respond well to this treatment approach.
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You will receive dose-dense chemotherapy given in intensive cycles before surgery for your breast cancer. The trial will monitor your response to treatment and gather information about biomarkers that might predict who benefits most from this approach. You'll need to complete all scheduled clinic visits and follow-up appointments as planned by your care team.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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