Plain-English translation of NCT05728359 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are trying to understand why some people recover better than others after severe heart failure, particularly when it happens alongside a heart attack. This study will collect blood samples and genetic information from about 300 patients across European hospitals to identify genetic patterns that might predict who will do well with different types of treatment support — including medicine alone, a heart-lung bypass machine, or a specialized mechanical pump.
Severe heart failure is life-threatening and doctors don't yet fully understand which patients will benefit most from different treatments. By studying the genetic makeup of patients with this condition, researchers hope to find patterns that could help doctors choose the best treatment approach for each person in the future.
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If you qualify, you will be enrolled at one of 8–10 heart centers across Europe during your hospital stay for heart failure treatment. You'll have a blood sample taken for genetic analysis, and researchers will collect information from your medical records about your condition and how you respond to treatment. The study is observational, meaning researchers are watching and recording what happens naturally with your medical care — you won't be asked to take a new medication or try an experimental therapy.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United Kingdom
Barts & The London NHS Trust
Collaborators
University of Oxford
Enrollment target
~300 participants
Started
August 2022
Primary completion
November 2026
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in November 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Alastair Proudfoot
Barts Heath NHS trust
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.