Plain-English translation of NCT05728697 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing a new ultrasound imaging method called endoscopic ultrasound shear wave elastography (EUS-SWE) to detect liver scarring in people with elevated body weight and fatty liver disease. The new technique works through the stomach using a thin ultrasound probe, which may work better in people with obesity than traditional ultrasound approaches. Researchers want to understand if this imaging method can accurately identify early-stage liver damage so doctors can intervene sooner.
Fatty liver disease is very common and can progress to more serious liver damage over time, but current methods to detect scarring are either risky (requiring a needle biopsy), expensive, or less accurate in people with obesity. This trial exists to see if the new ultrasound technique could provide a safer, more affordable, and more reliable way to screen for liver scarring in people who need it most.
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If you join, you will undergo an endoscopic ultrasound procedure during which doctors will perform the new ultrasound imaging technique on your liver. You will also have a liver biopsy (a small tissue sample) taken either at the same time or within 6 months to compare the new imaging results with the tissue findings. The study involves 150 participants total and is currently recruiting at Brigham and Women's Hospital.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States