Testing a water pill strategy for high blood pressure in kidney disease

This trial is testing a new approach to controlling high blood pressure in people with moderate to severe chronic kidney disease. Instead of the usual way doctors add more blood pressure medicines, this study tests whether using diuretics (water pills) as the second medication works better. The goal is to see if this medication strategy reduces heart attacks, strokes, kidney failure, and death better than standard care.

High blood pressure is the leading cause of serious complications in people with kidney disease, but doctors don't have clear guidelines on which medications work best as the second line of treatment. Research suggests that many people with kidney disease and uncontrolled blood pressure have excess fluid in their bodies, and this medication approach may address that root problem more effectively than current standard practice.