Plain-English translation of NCT05734625 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether nerve block injections — a type of local anesthetic injection given in the scalp — can quickly stop migraines and prevent future ones. You would receive either 2 injections (focused on one nerve) or 10 injections (targeting multiple nerves across the scalp). The researchers want to see which approach works better at stopping your migraine pain within 20 minutes and keeping migraines from coming back over the next 12 weeks.
Nerve blocks have shown promise for treating episodic migraines, but doctors aren't sure yet whether injecting more nerves across the scalp is better than injecting just one nerve. This trial will help answer that question so patients have a clearer, more effective option for both immediate migraine relief and long-term prevention.
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You would come in for injections in your scalp — either 2 injections in one location or 10 injections across multiple areas, depending on which group you're randomly assigned to. The researchers will check that the injections are working by testing if the scalp feels numb. You'll report how much pain relief you feel at 20 minutes, 2 hours, and 24 hours after the procedure. Then you'll track your migraines over the next 12 weeks to see if you have fewer migraines, less severe migraines, or miss fewer days of work or school.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
United States