Plain-English translation of NCT05734625 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 2 โ Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether injecting local anesthetic medication into multiple nerves in the scalp provides better relief from episodic migraines than injecting into just one nerve. Researchers at Mayo Clinic want to see if targeting more nerves helps with both immediate headache pain and prevents future migraines over several months.
Nerve block injections have shown promise for treating migraines, but most previous studies only tested one nerve. This trial aims to find out whether anesthetizing multiple nerves at once works even better and whether patients have fewer missed work days and emergency room visits when receiving this more comprehensive treatment.
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If you join this trial, you will receive either two injections (into one nerve on each side of your head) or ten injections (targeting multiple nerves across your scalp) โ your group will be randomly assigned. After your injection visit, you will report on your headache pain, missed work or activities, and any emergency room visits once a month for three months. The entire study lasts about six months, and researchers will track how much your migraines improve and how often you need emergency care.
AI-generated summary from trial data ยท Jun 1, 2026 ยท Not medical advice
United States