Plain-English translation of NCT05736965 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing combined with two other medications ( and ) to treat newly diagnosed acute myeloid leukemia — a serious blood cancer. The three-drug combination is being studied in people who either cannot tolerate intensive chemotherapy because of other health conditions, or who choose not to receive it. Researchers want to see if this gentler treatment approach works well and is safe.
Many people newly diagnosed with this blood cancer are too frail or have other health problems that make standard intensive chemotherapy too risky. This trial exists to find out whether this medication combination can work effectively for these patients who have limited treatment options.
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You would receive treatment in 28-day cycles at a hospital or clinic. On specific days each cycle, you would take by mouth, receive injections, and take by mouth at increasing doses. If you achieve complete remission, you may be eligible for a stem cell transplant; otherwise, you continue the treatment until your disease improves significantly or side effects become too difficult to manage. The trial will monitor your blood counts, organ function, and overall health throughout your participation.
AI-generated summary from trial data · Oct 22, 2026 · Not medical advice
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