Plain-English translation of NCT05737693 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether —a medication that may help the brain learn and change more quickly—can boost the effectiveness of trauma-focused counseling for PTSD. Researchers believe that combining infusions with intensive psychotherapy over seven days might help reduce PTSD symptoms faster than treatment alone, by creating a unique window when the brain is most able to process and heal from trauma.
PTSD can take months or longer to treat with therapy alone. This medication is thought to enhance the brain's ability to form new memories and let go of traumatic ones, so the goal is to compress months of healing into a single intensive week.
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You would attend a seven-day intensive program. On day two, you'd receive your first medication infusion while your brain activity is scanned. Days three through six involve 60–90 minute therapy sessions focused on processing your trauma. On day four, you'd receive a second medication infusion. Throughout, nurses and doctors monitor your heart rate and blood pressure. On day seven, you'd have a final brain scan to measure improvement. A nurse stays with you during and after each infusion to ensure your safety and comfort.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Israel