Plain-English translation of NCT05743140 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing whether a non-invasive eye imaging technique called optical coherence tomography angiography (OCTA) can help identify coronary microvascular disease — a condition where tiny blood vessels in the heart don't work properly. Currently, doctors use several different tests to diagnose this condition, but many are expensive, time-consuming, or involve radiation. Researchers believe that examining the tiny blood vessels in the back of your eye might help detect heart microvascular problems without needing invasive or risky procedures.
Many patients experience chest pain and show signs of heart strain on tests, but doctors find no major blockages in their heart arteries — a condition called coronary microvascular disease that increases the risk of serious heart events. Existing diagnostic tests for this condition are costly, time-consuming, or involve radiation exposure, so this study aims to find a safer, simpler screening method by exploring whether eye imaging can reliably detect the heart condition.
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If you qualify, you will undergo a special eye scan called optical coherence tomography angiography (OCTA), which uses infrared light to take detailed pictures of the tiny blood vessels in the back of your eye — a painless, non-invasive test that takes just minutes. Your eye scan results will be compared with measurements from your recent heart angiography to see if the eye imaging can reliably detect heart microvascular problems. The study involves approximately 400 participants total, and your participation would help researchers determine whether this simple eye test could become a useful screening tool for heart disease in the future.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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