Plain-English translation of NCT05743374 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether changing your diet can help control ulcerative colitis symptoms. Researchers want to know if avoiding certain food additives—like thickeners and preservatives found in many processed foods—can reduce inflammation and improve your symptoms better than standard dietary advice alone. About 70 people with moderately active ulcerative colitis will participate.
Many people with ulcerative colitis struggle to manage their symptoms even with medication. This trial exists because preliminary evidence suggests that certain food additives might trigger or worsen inflammation in the gut, so researchers want to see if eliminating them could be a simple, safe way to help.
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You will be randomly assigned to either continue your normal diet with standard advice, or to follow a diet that eliminates certain food additives (like carrageenan, CMC, and polysorbates). At the start and end of the study, you'll keep a 4-day food diary and answer questions about what you eat. Researchers will track your symptoms (like diarrhea, blood in stool, and abdominal pain), take blood tests to measure inflammation, and collect stool samples to examine your gut bacteria.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
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