Plain-English translation of NCT05745441 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how the timing of your evening meal affects your metabolism — specifically, how your body burns dietary fat. This study will have you eat dinner at two different times (early and late) while staying overnight in a research facility, and researchers will measure how your body processes the food. The goal is to learn whether eating dinner close to your normal bedtime affects your metabolism differently than eating dinner several hours before bed.
Obesity and prediabetes are major health challenges, and scientists suspect that when we eat during the day — not just what we eat — may play a role in how our bodies store or burn fat. This research could eventually help doctors give better advice about meal timing for people trying to manage their weight or blood sugar.
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First, you'll visit Johns Hopkins to have your circadian rhythm (body's natural clock) measured through a simple test. Then, you'll stay overnight at the NIH research facility twice — about 3 to 4 weeks apart — for two separate 24-hour metabolic chamber visits. At each visit, you'll eat a standardized dinner (one early, one late) and drink a specially labeled fat compound so researchers can track how your body processes it. All your meals, sleep timing, and activities will be carefully controlled to measure the effects of dinner timing on your metabolism.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States