Plain-English translation of NCT05745805 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how COVID-19 affects the brain and nervous system during and after infection. This study will follow people who had mild or moderate COVID-19 at multiple time points—right after infection, then 3 months later, and again at 12 months—collecting brain scans, blood samples, and information about mood and mental health. By comparing these results to people who never had COVID-19, the researchers hope to identify warning signs that could predict long-term COVID-19 complications.
Many people experience ongoing problems after COVID-19 infection, such as brain fog, fatigue, and mood changes. Scientists don't yet fully understand what causes these problems or how to predict who will develop them. This study aims to find biological markers in the blood and brain that could help doctors identify and help people at risk for long-term COVID-19 effects.
You likely qualify if…
You likely don't qualify if…
If you're in the COVID-19 group, you'll visit one of nine hospitals three times over one year: once during your acute infection, again at 3 months, and again at 12 months. At each visit, you'll have a brain MRI scan, give a blood sample, and complete questionnaires about your mood and mental health. If you're a healthy control (never had COVID-19), you'll complete these same tests just once at the beginning of the study. The entire study takes about one year for the infected groups.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
China
Sponsor
First Affiliated Hospital Xi'an Jiaotong University
Collaborators
Nuclear 215 Hospital of Shaanxi Province, Yanan Traditional Chinese Medicine Hospital
Enrollment target
~600 participants
Started
January 2023
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in February 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ming Zhang, PhD
First Affiliated Hospital of Xian Jiaotong University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.