Plain-English translation of NCT05745961 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand if a protein called TSPO is increased in the lungs of people with pulmonary artery hypertension (a condition where blood pressure in lung arteries becomes dangerously high). They'll use two special imaging scans called PET scans to measure this protein. If successful, this imaging technique could help doctors monitor how well treatments are working without invasive procedures.
Currently, doctors don't have a good non-invasive way to track whether medications are helping pulmonary artery hypertension patients. This study aims to develop a new imaging method that could give doctors a better window into what's happening inside the lungs and help guide treatment decisions.
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You would come in for two PET imaging scans of your lungs. In the first scan, you'll receive an injection of a radioactive tracer and then lie still inside a PET scanner for about 90 minutes while it takes pictures. In the second scan (performed on a separate visit), you'll receive a non-radioactive medication followed by another PET scan using the same tracer. These scans help researchers measure the inflammation marker in your lungs.
AI-generated summary from trial data · Aug 26, 2026 · Not medical advice
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