Plain-English translation of NCT05746221 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
The INSVD study is looking at whether changes in inflammation in your body can predict damage to the white matter of your brain (the tissue that helps different parts of your brain communicate) and whether it leads to memory or thinking problems. Researchers will follow 200 patients with small vessel disease at two hospitals—one in Cambridge, UK, and one in the Netherlands—to understand this connection better.
Small vessel disease is a common cause of stroke and cognitive decline in older adults, but doctors don't fully understand why some people's brains are more affected than others. This study aims to figure out whether measuring inflammation in the blood could help predict who will experience brain damage and memory problems, which might lead to better treatments in the future.
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If you join this study, you would visit the hospital at the start and then be followed for two years with periodic check-ins. During visits, you'll have blood tests to measure inflammation, brain MRI scans to look for changes in white matter, and cognitive tests to check your thinking and memory. The research team will also review your medical records to track your health over time. There is no medication to take—this is an observational study where researchers simply monitor your health and gather information to understand the connection between inflammation and brain damage.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
Netherlands
United Kingdom
Sponsor
University of Cambridge
Collaborators
Radboud University Medical Center, Wolfson Brain Imaging Centre
Enrollment target
~200 participants
Started
August 2022
Primary completion
July 2026
Age range
40 Years and older
Last updated on clinicaltrials.gov in February 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Hugh S Markus
University of Cambridge
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.