Plain-English translation of NCT05748158 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand why people who lose weight often gain it back. This study will have you complete a 37-week weight loss program focused on eating less and moving more, then follow you for a year afterward. Scientists will measure your metabolism, eating patterns, physical activity, and other body processes to figure out which changes predict whether you'll keep the weight off or regain it.
Weight regain after weight loss is a frustrating and common problem. This research aims to identify the specific body and behavioral changes that determine whether someone can maintain their weight loss long-term, which could eventually lead to better strategies to help people succeed.
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You'll start with a behavioral weight loss program lasting 37 weeks, where you'll work on reducing calories and increasing physical activity. After losing at least 7 percent of your body weight, you'll enter a 12-month monitoring phase with check-in visits at 4 months and 12 months. Throughout the study, you'll complete various tests including fitness assessments, muscle biopsies, brain imaging scans, blood draws, and questionnaires about your eating habits and mood—all designed to measure how your body is responding to weight loss.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
United States