Plain-English translation of NCT05748717 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This research study is looking at how sickle cell disease affects blood vessels and blood flow in children's brains. Researchers want to understand whether certain blood vessel measurements can help predict which children are at higher risk for stroke. By comparing children with normal and abnormal blood flow patterns, they hope to find better ways to protect children with sickle cell disease from serious complications.
Sickle cell disease damages blood vessels over time, which can lead to stroke—one of the most serious complications for children with this condition. Right now, doctors use one test (called Transcranial Doppler) to check stroke risk, but researchers think measuring other blood vessel health markers might give a more complete picture and help them predict problems earlier.
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If you join this study, you'll visit the Sickle Cell Unit in Kingston, Jamaica, where researchers will do several non-invasive tests: a special ultrasound to measure blood flow in your brain, another ultrasound to check how stiff your arteries are, and blood pressure measurements. You'll also have some blood tests done. The visits are observational only—meaning no medication is given—and researchers will simply measure and compare your results with those of other children in the study to look for patterns.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Jamaica