Plain-English translation of NCT05753059 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether adding and — two different types of diuretics (water pills) — to your existing bumetanide treatment might help your heart work better when you've become resistant to diuretics alone. Diuretic resistance happens when your body stops responding to water pills the way it should, making it harder to manage fluid buildup in heart failure. The study wants to understand whether these medication combinations can overcome that resistance.
Many people with heart failure eventually stop responding well to their water pills, which makes managing their condition much more difficult. Researchers want to find out whether combining these medications in specific ways might help restore the body's response and give patients better options for managing their condition.
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You will take different combinations of medications over a 3-week period, with study visits on days 0, 7, 14, and 21. During the study, you'll receive either a combination of medications or a placebo (inactive pill) — neither you nor the researchers will know which until the study ends. You'll switch between different medication combinations throughout the 3 weeks so researchers can compare how each one works for you. Blood tests and urine collection will track how your body responds to each treatment.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
Yale University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment target
~50 participants
Started
August 2023
Primary completion
June 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Veena Rao
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.