Plain-English translation of NCT05753748 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether people with Barrett's esophagus and early-stage cell changes (low-grade dysplasia) benefit more from regular surveillance with biopsies or from radiofrequency ablation, a procedure that uses heat to remove the abnormal tissue. The study will follow about 680 patients across multiple medical centers for up to 4 years to see which approach better prevents cancer development.
Doctors currently disagree on the best way to manage Barrett's esophagus with early cell changes—some prefer watching and monitoring closely, while others recommend treating it right away. This trial will provide clear evidence about which approach keeps patients safer and healthier.
You likely qualify if…
You likely don't qualify if…
If you are randomized to surveillance, you will have endoscopy procedures every 6 months to 1 year (depending on when your dysplasia was first found) where the doctor takes small tissue samples. If you are randomized to treatment, you will receive radiofrequency ablation procedures every 2–3 months until the abnormal tissue is completely gone (or up to 5 treatments), then switch to surveillance visits. Either way, you'll have phone check-ins every 6 months and visits that may last up to 4 years.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
United States