Plain-English translation of NCT05756179 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Rheumatoid Arthritis research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a combination of two natural compounds called diosmin and hesperidin to see if they can help reduce inflammation and pain in people with rheumatoid arthritis. You would take this medication alongside your regular arthritis treatment (methotrexate) for three months. Researchers want to know if the medication can improve how you feel and function, and whether it can protect your liver from side effects of your existing treatment.
Methotrexate is an effective arthritis medication, but it can sometimes cause liver problems with long-term use. This trial explores whether adding this natural supplement might reduce inflammation better while also protecting your liver from potential damage.
You likely qualify if…
You likely don't qualify if…
If you join this study, you would take the supplement twice daily (as tablets) for three months while continuing your regular methotrexate treatment. The study team would assess your joint pain, swelling, and overall function at visits, and check your liver health through blood tests. The entire active participation period is three months.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
Egypt
Phase
Large-scale testing
Sponsor
Alexandria University
Enrollment target
~80 participants
Started
July 2023
Primary completion
September 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
19 Years – 65 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
AHMED ABDELBAR, MSc
College of Pharmacy - Arab Academy for Science and Technology
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.